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Location：Home > Biochemicals > Protein Inhibitors
CHIR-98014 (CAS: 252935-94-7)
Catalog #：EBC51075
CHIR-98014 (CAS: 252935-94-7)
  SKU-Pack Size Availability Size Price
EBC51075-1ML In Stock 1mL(10mM in DMSO) ￥1090.00
EBC51075-2MG In Stock 2mg ￥590.00
EBC51075-5MG In Stock 5mg ￥990.00
EBC51075-10MG In Stock 10mg ￥1590.00
EBC51075-25MG In Stock 25mg ￥2990.00
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Product Information
Synonym(s) CHIR 98014, CHIR-98014, CT98014
Chemical Name N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-Pyridinediamine
Application CHIR-98014 is a selective and ATP-competitive inhibitor of GSK-3β
CAS Number 252935-94-7
Purity ≥99.0%
Molecular Weight 486.31
Molecular Formula C₂₀H₁₇Cl₂N₉O₂
SMILES C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N
Target & IC50 GSK-3 β: IC50 = 0.58 nM
GSK-3 α: IC50 = 0.65 nM
Solubility DMSO: 8 mg/mL (16.45 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.0563 ml 10.2815 ml 20.5630 ml
5 mM 0.4113 ml 2.0563 ml 4.1126 ml
10 mM 0.2056 ml 1.0282 ml 2.0563 ml
50 mM 0.0411 ml 0.2056 ml 0.4113 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

CHIR-98014 is a selective and ATP-competitive inhibitor of Glycogen Synthase Kinase 3β(GSK-3β) with Ki values of 0.87 nM. In addition, CHIR-98014 displays 500 to greater than 1000-fold selectivity towards GSK3 than other protein kinases such as cdc2 and erk2. The inhibitory effects of CHIR-98014 are similar for both α and β isoforms of GSK-3.
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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