Protein Agonists, Antagonists and Activators - CH 223191 (CAS: 301326-22-7)

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CH 223191 (CAS: 301326-22-7)

Catalog #：EBC51074

Datasheet

CH 223191 (CAS: 301326-22-7)

SKU-Pack Size	Availability	Size	Price
EBC51074-1ML	In Stock	1mL(10mM in DMSO)	￡75.90
EBC51074-5MG	In Stock	5mg	￡75.90
EBC51074-10MG	In Stock	10mg	￡108.90
EBC51074-50MG	In Stock	50mg	￡295.90

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Product Information

Synonym(s)

AhR Antagonist, CH223191, AGN-PC-0KP4EW

Application

CH 223191 is a potent and specific aryl hydrocarbon receptor inhibitor

CAS Number

301326-22-7

Purity

≥99.0%

Molecular Weight

333.39

Molecular Formula

C₁₉H₁₉N₅O

SMILES

CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C

Target & IC50

TCDD-induced AhR transcription activity: IC50 = 30 nM

Solubility

DMSO: 33.3 mg/mL (100 mM)
Ethanol: 33.3 mg/mL (100 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.9995 ml	14.9974 ml	29.9949 ml
5 mM	0.5999 ml	2.9995 ml	5.9990 ml
10 mM	0.3000 ml	1.4997 ml	2.9995 ml
50 mM	0.0600 ml	0.2999 ml	0.5999 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

CH 223191 is a specific and potent antagonist to the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor that is involved in drug and xenobiotic metabolism. Unlike other AhR antagonists, it does not react with the estrogen receptor and is observed to effect AhR-dependent reporter gene expression in human, mouse, rat, and guinea pig cell lines. CH223191 is reported to exhibit AHR-independent pro-proliferative properties.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol