Protein Agonists, Antagonists and Activators

CD 437 (CAS: 125316-60-1)

Catalog #：EBC51073

CD 437 (CAS: 125316-60-1)

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Product Information

Synonym(s)

AHPN

Chemical Name

6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid

Application

CD 437 is a cell-permeable RARγ-selective agonist

CAS Number

125316-60-1

Purity

≥99.0%

Molecular Weight

398.4

Molecular Formula

C₂₇H₂₆O₃

SMILES

O=C(O)c1ccc2cc(ccc2c1)c6cc(C5C3CC4CC5CC(C3)C4)c(O)cc6

Target & IC50

ADMET: IC50 = 0.33 μM
IGROV-1: IC50 = 0.35 μM

Solubility

DMSO : 150 mg/mL (376.42 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
CD 437 is a synthetic, cell-permeable, retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that CD437/AHPN effectively functions as an ER stress inducer. CD 437 is an activator of RAR γ.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol