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EED-226 (CAS: 2083627-02-3)
Catalog #：EBC51034
EED-226 (CAS: 2083627-02-3)
  SKU-Pack Size Availability Size Price
EBC51034-1ML In Stock 1mL(10mM in DMSO) ￥790.00
EBC51034-5MG In Stock 5mg ￥790.00
EBC51034-10MG In Stock 10mg ￥1090.00
EBC51034-25MG In Stock 25mg ￥1990.00
EBC51034-50MG In Stock 50mg ￥3290.00
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Product Information
Synonym(s) EED226, EED 226
Chemical Name N-(Furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)[1,2,4]-triazolo[4,3-c]pyrimidin-5-amine
Application EED-226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor
CAS Number 2083627-02-3
Purity ≥99.5%
Molecular Weight 369.4
Molecular Formula C₁₇H₁₅N₅O₃S
SMILES CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(N3C2=NN=C3)NCC4=CC=CO4
Target & IC50 EED;=82nM(Kd)
PRC2;=114nM(Kd)
Solubility DMSO: 73 mg/mL (197.62 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.7071 ml 13.5354 ml 27.0709 ml
5 mM 0.5414 ml 2.7071 ml 5.4142 ml
10 mM 0.2707 ml 1.3535 ml 2.7071 ml
50 mM 0.0541 ml 0.2707 ml 0.5414 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

EED-226 is a potent, selective, allosteric Polycomb repressive complex 2 (PRC2) inhibitor (IC₅₀ = 23.4 nM). EED-226 binds to the H3K27me3 binding pocket of EED (Embryonic Ectoderm Development) to allosterically inhibit PRC2. EED-226 induces robust and sustained tumor regression in EZH2MUT preclinical DLBCL model.
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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