Other Biochemicals - EED-226 (CAS: 2083627-02-3)

EED-226 (CAS: 2083627-02-3)

Catalog #：EBC51034

EED-226 (CAS: 2083627-02-3)

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Product Information

Synonym(s)

EED226, EED 226

Chemical Name

N-(Furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)[1,2,4]-triazolo[4,3-c]pyrimidin-5-amine

Application

EED-226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor

CAS Number

2083627-02-3

Purity

≥99.5%

Molecular Weight

369.4

Molecular Formula

C₁₇H₁₅N₅O₃S

SMILES

CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(N3C2=NN=C3)NCC4=CC=CO4

Target & IC50

EED;=82nM(Kd)
PRC2;=114nM(Kd)

Solubility

DMSO: 73 mg/mL (197.62 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
EED-226 is a potent, selective, allosteric Polycomb repressive complex 2 (PRC2) inhibitor (IC₅₀ = 23.4 nM). EED-226 binds to the H3K27me3 binding pocket of EED (Embryonic Ectoderm Development) to allosterically inhibit PRC2. EED-226 induces robust and sustained tumor regression in EZH2MUT preclinical DLBCL model.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol