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Location：Home > Biochemicals > Protein Inhibitors
AT-406 (CAS: 1071992-99-8)
Catalog #：EBC51037
Datasheet
AT-406 (CAS: 1071992-99-8)
  SKU-Pack Size Availability Size Price
EBC51037-1ML In Stock 1mL(10mM in DMSO) ￥1890.00
EBC51037-1MG In Stock 1mg ￥490.00
EBC51037-5MG In Stock 5mg ￥1290.00
EBC51037-10MG In Stock 10mg ￥1890.00
EBC51037-25MG In Stock 25mg ￥3790.00
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Product Information
Synonym(s) AT 406, AT406 cpd, SM-406, SM 406, SM406cpd
Chemical Name (5S,8S,10aR,Z)-N-benzhydryl-5-((Z)-((S)-1-hydroxy-2-(methylamino)propylidene)amino)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carbimidic acid
Application AT-406 is a potent and orally bioavailable antagonist of multiple inhibitor of apoptosis proteins (IAPs)
CAS Number 1071992-99-8
Purity ≥99.0%
Molecular Weight 561.71
Molecular Formula C₃₂H₄₃N₅O₄
SMILES O=C([C@@H]1CC[C@@](CCN(C(CC(C)C)=O)C[C@@H]2NC([C@@H](NC)C)=O)([H])N1C2=O)NC(C3=CC=CC=C3)C4=CC=CC=C4
Target & IC50 XIAP: IC50 = 66.4 nM
cIAP1: IC50 = 1.9 nM
cIAP2: IC50 = 5.1 nM
Solubility DMSO: 93 mg/mL (165.6 mM)
Ethanol: 93 mg/mL (165.6 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.7803 ml 8.9014 ml 17.8028 ml
5 mM 0.3561 ml 1.7803 ml 3.5606 ml
10 mM 0.1780 ml 0.8901 ml 1.7803 ml
50 mM 0.0356 ml 0.1780 ml 0.3561 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

AT406 (SM-406, ARRY-334543) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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