Aphidicolin is a diterpene fungal metabolite that blocks the cell cycle at early S-phase. In addition, Aphidicolin is a tetracyclic diterpene antibiotic with antiviral and antimitotic properties. Aphidicolin was first isolated from Cephelosporium aphidicola. Aphidicolin is a specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin.