Anisomycin (CAS: 22862-76-6)
|
SKU-Pack Size | Availability | Size | Price | |
EBC51014-1ML | In Stock | 1mL(10mM in DMSO) | ¥490.00 | |
EBC51014-10MG | In Stock | 10mg | ¥490.00 | |
EBC51014-25MG | In Stock | 25mg | ¥790.00 | |
EBC51014-50MG | In Stock | 50mg | ¥990.00 | |
EBC51014-100MG | In Stock | 100mg | ¥1690.00 |
Please Select The Country You Are In To Find Your Local Distributor. |
北京美瑞克生物科技有限公司 | Phone: +86 010-62890160 / 13691184142(微信同号) | |
2 / F, 128 malianwa North Road, Haidian District, | E-mail: mrkbio@163.com | |
China | Beijing China | Website: www.mrkbio.com |
Product Information | |||||||||||||||||||||
Synonym(s) | Flagecidin, NSC 76712 | ||||||||||||||||||||
Chemical Name | (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate | ||||||||||||||||||||
Application | Anisomycin is activator of JNK (c-Jun N-terminal kinases) and p38 | ||||||||||||||||||||
CAS Number | 22862-76-6 | ||||||||||||||||||||
Purity | ≥99.0% | ||||||||||||||||||||
Molecular Weight | 265.31 | ||||||||||||||||||||
Molecular Formula | C₁₄H₁₉NO₄ | ||||||||||||||||||||
SMILES | CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O | ||||||||||||||||||||
Target & IC50 | JNK, DNA synthesis | ||||||||||||||||||||
Solubility | DMSO: 26.5 mg/mL (100 mM) Ethanol: 13.3 mg/mL (50 mM) |
||||||||||||||||||||
Preparing Stock Solutions |
|
||||||||||||||||||||
Shipping | Gel Pack | ||||||||||||||||||||
Storage | Store at -20°C | ||||||||||||||||||||
Research Use | For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use. |
Product Description | |
Anisomycin is a phenylpyrolidine derivative shown to strongly activate the stress-induced MAP kinases JNK and p38. This activity results in the induction of the immediate-early genes: c-Fos, c-Jun, Fos B, Jun B and Jun D, and enhanced phosphorylation of p54/nrb, ATF-2, ERK, Caldesmon, IRS-1 and IRS-2. This compound behaves as a true signaling agonist, and has been implicated to play an important role in hyperosmolarity and UV-stimulated responses. Anisomycin has also been shown to increase the phosphorylation of p70 S6 kinase α. |
Specific Protocols | |