Protein Agonists, Antagonists and Activators - Anisomycin (CAS: 22862-76-6)

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Anisomycin (CAS: 22862-76-6)

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Catalog #：EBC51014

Datasheet

Anisomycin (CAS: 22862-76-6)

SKU-Pack Size	Availability	Size	Price
EBC51014-1ML	In Stock	1mL(10mM in DMSO)	$73.50
EBC51014-10MG	In Stock	10mg	$73.50
EBC51014-25MG	In Stock	25mg	$118.50
EBC51014-50MG	In Stock	50mg	$148.50
EBC51014-100MG	In Stock	100mg	$253.50

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Product Information

Synonym(s)

Flagecidin, NSC 76712

Chemical Name

(2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate

Application

Anisomycin is activator of JNK (c-Jun N-terminal kinases) and p38

CAS Number

22862-76-6

Purity

≥99.0%

Molecular Weight

265.31

Molecular Formula

C₁₄H₁₉NO₄

SMILES

CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O

Target & IC50

JNK, DNA synthesis

Solubility

DMSO: 26.5 mg/mL (100 mM)
Ethanol: 13.3 mg/mL (50 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.7692 ml	18.8459 ml	37.6918 ml
5 mM	0.7538 ml	3.7692 ml	7.5384 ml
10 mM	0.3769 ml	1.8846 ml	3.7692 ml
50 mM	0.0754 ml	0.3769 ml	0.7538 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

Anisomycin is a phenylpyrolidine derivative shown to strongly activate the stress-induced MAP kinases JNK and p38. This activity results in the induction of the immediate-early genes: c-Fos, c-Jun, Fos B, Jun B and Jun D, and enhanced phosphorylation of p54/nrb, ATF-2, ERK, Caldesmon, IRS-1 and IRS-2. This compound behaves as a true signaling agonist, and has been implicated to play an important role in hyperosmolarity and UV-stimulated responses. Anisomycin has also been shown to increase the phosphorylation of p70 S6 kinase α.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol