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KU-55933 (CAS: 587871-26-9)
Catalog #£ºEBC51008
  SKU-Pack Size Availability Size Price
EBC51008-1ML In Stock 1mL(10mM in DMSO) €89.70
EBC51008-5MG In Stock 5mg €89.70
EBC51008-25MG In Stock 25mg €232.70
EBC51008-50MG In Stock 50mg €349.70
EBC51008-100MG In Stock 100mg €453.70
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Product Information
Synonym(s) ATM Kinase Inhibitor
Chemical Name 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
Application ATM Kinase Inhibitor is a cell-permeable, potent, selective and ATP-competitive ATM inhibitor
CAS Number 587871-26-9
Purity ¡Ý99.0%
Molecular Weight 395.49
Molecular Formula C₂₁H₁₇NO₃S₂
SMILES C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4
Target & IC50 Atm: IC50 = 13 nM
mTOR: IC50 = 9.3 ¦ÌM
PI3K: IC50 = 16.6 ¦ÌM
Solubility DMSO: 39.6 mg/mL (100 mM)
Ethanol: 19.8 mg/mL (50 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.5285 ml 12.6425 ml 25.2851 ml
5 mM 0.5057 ml 2.5285 ml 5.0570 ml
10 mM 0.2529 ml 1.2643 ml 2.5285 ml
50 mM 0.0506 ml 0.2529 ml 0.5057 ml
Shipping Gel Pack
Storage Store at -20¡ã C
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Product Description

ATM Kinase Inhibitor (KU 55933) is a cell-permeable, potent, selective and ATP-competitive inhibitor of ATM (Ataxia telangiectasia mutated), a serine/threonine protein kinase, that exhibits an IC50 of 13 nmol/L and a Ki of 2.2 nmol/L. ATM is rapidly and specifically activated in response to DNA double-strand breaks in eukaryotic cells and signals to cell cycle and DNA repair components by phosphorylating downstream targets such as p53, CHK2, NALP2 (NBS1), and BRCA1.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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