Protein Inhibitors - SB 202190 (CAS: 152121-30-7)

SB 202190 (CAS: 152121-30-7)

Catalog #：EBC51002

SB 202190 (CAS: 152121-30-7)

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Product Information

Synonym(s)

SB-202190, SB202190, FHPI, 4-[4-(4-Fluorphenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol

Chemical Name

4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole

Application

SB 202190 is an inhibitor of the isoforms p38α and p38β

CAS Number

152121-30-7

Purity

≥98%

Molecular Weight

331.34

Molecular Formula

C₂₀H₁₄FN₃O

SMILES

FC1=CC=C(C2=C(C3=CC=NC=C3)NC(C4=CC=C(O)C=C4)=N2)C=C1

Target & IC50

p38α: IC50 = 14.3 nM (human)
p38 MAP kinase: IC50 = 30 nM
p38 β: IC50 = 100 nM
Toxoplasma gondii: IC50 = 1 μM

Solubility

DMSO: 33.1 mg/mL (100 mM)
PS: < 1 mg/ml refers to the product slightly soluble or insoluble

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20° C

Research Use

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Product Description
SB 202190 is a selective and potent p38 MAP kinases inhibitor, binding to its ATP pocket. It has negligible inhibiting properties on other MAP kinases such as ERKs and JNKs. SB 202190 is reported to be used to induce cardiomyocyte differentiation from human embryonic stem cells and increase neural stem cell self-renewal.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol