Q9NQ25

SLAMF7 also known as novel Ly9, CS1, 19A24 or CRACC, is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells. SLAMF7 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein). In humans, SLAMF7 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. SLAMF7 recruits and associates with EAT-2, a protein closely related to SAP. EAT-2 induces phosphorylation of SLAMF7 which then, upon ligand binding, activates downstream cytotoxicity effectors PLCγ and PI 3-kinase. In mice, the EAT-2 association with SLAMF7 has an inhibitory effect on the activation of NK cells.