Q2M3G0

ABCB5 (ATP-binding cassette sub-family B member 5), also known as P-glycoprotein ABCB5 or ABCB5 P-gp, is a 812 amino acid multi-pass membrane protein that belongs to the superfamily of ABC transporters. Expressed ubiquitously, ABCB5 contains two ABC transporter domains and one ABC transmembrane type-1 domain and is responsible for the resistance to doxorubicin of a subset of malignant melanomas. It is suggested ABCB5 inhibits tumor growth and is thought to be a novel drug transporter and chemoresistance mediator in melanoma cells. Two isoforms of ABCB5, designated alpha and beta, exist due to alternative splicing events.