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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP | 43 | Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:1000-5000 IP=1:10-100 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Caspase-11 Rabbit Monoclonal Antibody detects endogenous levels of Caspase-11 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Caspase-11 is a crucial inflammatory caspase in mice that plays a significant role in the innate immune response, particularly in the detection of intracellular lipopolysaccharides (LPS) from Gram-negative bacteria. Upon recognition of LPS, caspase-11 becomes activated and induces pyroptosis, a form of programmed cell death characterized by cell swelling and lysis, leading to the release of pro-inflammatory cytokines like interleukin-1β (IL-1β). This process is essential for controlling bacterial infections but can contribute to pathological inflammation if unregulated. Caspase-11 also influences the synthesis of functional cytokines and has been implicated in neuroinflammatory conditions such as experimental autoimmune encephalomyelitis (EAE). Understanding the function of caspase-11 is important for insights into sepsis, neurodegenerative diseases, and other inflammatory disorders. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells, using Caspase-11 Rabbit Monoclonal Antibody (EAB22740) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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