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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 33 | Human, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Cleaved Caspase-6 p18 (Asp179) Rabbit Polyclonal Antibody detects endogenous levels of Caspase-6 p18 protein resulting from cleavage adjacent to Asp179. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Caspase-6 also known as MCH2, CASP6 is a member of the cysteine-aspartic acid protease (caspase) family of enzymes. which are crucial for the execution of apoptosis, a programmed cell death process essential for maintaining cellular homeostasis and development. Caspase-6 is primarily located in the cytoplasm and is activated in response to apoptotic signals, where caspase-6 plays a pivotal role in cleaving specific substrates that are vital for cellular integrity. Notably, caspase-6 has been shown to cleave nuclear lamins, which are integral to maintaining the structural integrity of the nuclear envelope and ensuring proper cellular morphology. The precise regulation of caspase-6 activity is critical, as dysregulation can lead to various pathological conditions, including neurodegenerative diseases and cancer. |
