| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG2b | Monoclonal | WB, IHC-P, IF/ICC, ELISA | 68 | Human, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:2000-10000 IHC-P=1:200-1000 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | GBP1 Mouse Monoclonal Antibody detects endogenous levels of GBP1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
GBP1(guanylate binding protein 1) is a member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GBP1′s ability to hydrolyze GMP to GTP through two consecutive cleavage steps underscores its importance in cellular signaling pathways. GBP1 is primarily localized in the cytoplasm and is expressed in endothelial cells of the vascular system, where interferon-gamma induces expression during macrophage activation. GBP1 plays a significant role in regulating matrix metalloproteinase-1 expression, which is involved in endothelial cell proliferation and invasiveness. GBP1 is integral to inflammatory cytokine regulation and provides protection against vesicular stomatitis and encephalomyocarditis viruses. |
