| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 55 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | AChRα1 Rabbit Polyclonal Antibody detects endogenous levels of AChRα1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
AChRα1 also known as ACHRA, ACHR-1, CHRNA is a component of the nicotinic acetylcholine receptor. AChRα1 plays a vital role in synaptic transmission at the neuromuscular junction, where AChRα facilitates rapid communication between nerve and muscle cells. AChRα receptor is composed of five subunits that form a transmembrane channel, allowing selective passage of ions when activated by acetylcholine. Proper functioning of AChRα1 is essential for muscle contraction and overall neuromuscular function, and any dysfunction can lead to severe conditions such as myasthenia gravis. Additionally, AChRα1 undergoes post-translational modifications, including glycosylation, which are critical for stability, localization, and function. These modifications can influence receptor sensitivity and overall efficacy of synaptic transmission, highlighting AChRα1 importance in both normal physiology and disease states. |
| Product Image Gallery | |
 Western blot analysis of extracts on U937, NIH/3T3 cells, using AChRα1 Rabbit Polyclonal Antibody (EAB12171) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue, using AChRα1 Rabbit Polyclonal Antibody (EAB12171) at 1:100 dilution.
 Immunofluorescence analysis of A549 cell, using AChRα1 Rabbit Polyclonal Antibody (EAB12171) at 1:200 dilution.
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