| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IHC-P, IF/ICC | 155 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | ASK1 Rabbit Monoclonal Antibody detects endogenous levels of ASK1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
ASK1 also known as MEKK5, MAP3K5 is a member of the MAP kinase kinase kinase subfamily. ASK1 plays a crucial role in cellular signaling pathways, particularly in the activation of mitogen-activated protein (MAP) kinase cascades, which are essential for mediating cellular responses to various extracellular stimuli, including stress and growth factors. ASK1 is primarily located in the cytoplasm, where ASK1 acts as a key regulator of apoptosis and inflammation by activating downstream kinases such as MEK-4 and MEK-3/MEK-6. This localization allows ASK1 to respond rapidly to cellular stress signals, thereby influencing cell survival and death decisions. ASK1′s ability to modulate these pathways underscores ASK1′s importance in various physiological and pathological processes, including cancer and neurodegenerative diseases. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Raji cells, using ASK1 Rabbit Monoclonal Antibody (EAB22808) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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