| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC | 68 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IP=1:10-100 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Lamin B2 Rabbit Monoclonal Antibody detects endogenous levels of Lamin B2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Lamin B2 also known LMNB2 is a B type nuclear lamin. Lamin B2 plays a crucial role in maintaining the structural integrity of the nuclear envelope, which is essential for proper cellular function and organization. Located on the nucleoplasmic side of the inner nuclear membrane, Lamin B2 is a key component of the nuclear lamina, providing mechanical support and anchoring chromatin. This structural role is vital for regulating gene expression and ensuring the stability of the nucleus during cell division. Additionally, Lamin B2 is subject to post-translational modifications, such as farnesylation and phosphorylation, which are important for its function and interactions within the cell. Increased phosphorylation of lamins has been observed prior to nuclear envelope disintegration, suggesting a regulatory mechanism that influences lamin associations and cellular responses during apoptosis. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, C6 cells, using Lamin B2 Rabbit Monoclonal Antibody (EAB22830) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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