| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IF/ICC | 81 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 IF/ICC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MCM7 Rabbit Monoclonal Antibody detects endogenous levels of MCM7 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MCM7 is a member of the mini-chromosome maintenance (MCM) protein family, MCM7 plays a crucial role in the regulation of DNA replication, ensuring that DNA is replicated only once per cell cycle. This is vital for maintaining genomic stability and preventing over-replication, which can lead to genomic instability and cancer. MCM7, along with other MCM proteins, contains an ATP-binding motif that facilitates the opening of double-stranded DNA in an ATP-dependent manner, a key step in the initiation of DNA replication. MCM7 expression peaks during the transition from the G1 to S phase of the cell cycle and is influenced by E2F transcription factors and various protein kinases. MCM7 interacts with other MCM proteins to form a complex that exhibits DNA helicase activity, essential for unwinding DNA strands during replication. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562, C6, HCT116 cells, using MCM7 Rabbit Monoclonal Antibody (EAB22196) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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