| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, IF/ICC, FC, ELISA | 30 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:100-500 IF/ICC=1:100-500 FC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Slug Mouse Monoclonal antibody detects endogenous levels of Slug protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Slug also known as SNAI2 is a member of the Snail family of C2H2-type zinc finger transcription factors. Slug plays a crucial role in embryonic development and cellular processes, particularly in the epithelial-to-mesenchymal transition (EMT), which is essential for processes such as tissue remodeling and organogenesis. Slug is primarily located in the nucleus, where Slug functions as a transcriptional repressor, binding to specific DNA sequences to inhibit the expression of genes that promote epithelial characteristics. This nuclear localization enables Slug to effectively regulate gene expression during critical developmental stages and in pathological conditions, such as cancer, where Slug contributes to tumor progression and metastasis by promoting cell migration and invasion. |
| Product Image Gallery | |
 Western blot analysis of extracts on MCF7 cells, using Slug Mouse Monoclonal antibody (EAB22537) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue, using Slug Mouse Monoclonal antibody (EAB22537) at 1:200 dilution.
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