| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IF/ICC | 76 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TRIF/TICAM1 Rabbit Monoclonal Antibody detects endogenous levels of TRIF/TICAM1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TRIF also known as TICAM-1 is an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, TRIF is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TRIF plays a crucial role in the immune response by mediating the signaling pathways activated by Toll-like receptor 3 (TLR3) in response to double-stranded RNA, which is a common viral signature. This interaction is vital for the production of interferon-beta, a key cytokine in antiviral defense, through the activation of transcription factors such as NF-kappaB, AP-1, and IRF3. The proper functioning of TIRF is essential for an effective immune response, and dysregulation can lead to impaired antiviral immunity or contribute to autoimmune diseases. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562 cells, using TRIF/TICAM1 Rabbit Monoclonal Antibody (EAB22348) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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