| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC | 26 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IP=1:10-100 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Bcl-xL Rabbit Monoclonal Antibody detects endogenous levels of Bcl-xL protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Bcl-xL is a member of the Bcl-2 family, Bcl-xL plays a crucial role in regulating apoptosis, which is essential for maintaining cellular homeostasis and preventing excessive cell death. By inhibiting apoptotic pathways, Bcl-xL contributes to cell survival in response to various stressors, making Bcl-xL particularly important in the context of cancer, where overexpression can lead to tumorigenesis and resistance to therapy. Bcl-xL is expressed as a 233 amino acid protein that shares 43% sequence identity with Bcl-2, and functions by forming heterodimers with pro-apoptotic proteins such as Bax and Bad, thereby modulating their activity and influencing the apoptotic process. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, K562, C6 cells, using Bcl-xL Rabbit Monoclonal Antibody (EAB21210) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 26 kDa; Observed band size: 30 kDa |
