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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG2b | Monoclonal | WB, IHC-P, IF/ICC, FC, ELISA | 124 | Human, Mouse, Rat, Pig, Rabbit |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:1000-5000 IHC-P=1:100-500 IF/ICC=1:100-500 FC=1:100-500 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PI3 Kinase p110α Mouse Monoclonal Antibody detects endogenous levels of PI3 Kinase p110α protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PI3 Kinase p110α plays a crucial role in cellular functions such as growth, proliferation, and survival, making the study of PI 3-kinase components vital for understanding various diseases, including cancer. PI3 Kinase p110α is particularly important as PI 3-kinase p110α is frequently mutated in several types of cancer, leading to aberrant signaling and uncontrolled cell growth. Understanding PI3 Kinase p110α interactions with PI3 kinase regulatory subunit p85 is essential, as p85 serves as an adapter that links PI3 Kinase p110α to activated protein tyrosine kinases, thereby facilitating the activation of downstream signaling pathways. PI3 Kinase p110α ability to interact with both p85α and p85β highlights PI3 Kinase p110α versatility and importance in the PI3 kinase signaling cascade, which is critical for maintaining cellular homeostasis and responding to extracellular signals. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Jurkat, HEK293, Mouse brain cells, using PI3 Kinase p110α Mouse Monoclonal Antibody (EAB22823) at 1:4000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
Predicted band size: 124 kDa; Observed band size: 110 kDa  Immunohistochemistry analysis of paraffin-embedded Mouse kidney tissue, using PI3 Kinase p110α Mouse Monoclonal Antibody (EAB22823) at 1:200 dilution.
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