| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IF/ICC, FC, ELISA | 125 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IF/ICC=1:100-500 FC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Jak3 Mouse Monoclonal Antibody detects endogenous levels of Jak3 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Jak3 (Janus kinase 3) is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. Jak3 plays a crucial role in the signaling pathways of the immune system, particularly in the lympho-hematopoietic system, where Jak3 regulates various cellular functions downstream of activated cytokine receptors. Jak3 is primarily located in the cytoplasm, where Jak3 interacts with cytokine receptor-associated proteins, facilitating the phosphorylation of Stat transcription factors. This interaction is vital for the transduction of signals that lead to the transcription of genes involved in immune responses, including those that promote cell proliferation, differentiation, and survival. The proper functioning of Jak3 is essential for maintaining a balanced immune response, and dysregulation of Jak3 activity can lead to autoimmune diseases and other inflammatory conditions. |
| Product Image Gallery | |
 Western blot analysis of extracts on Jurkat cells, using Jak3 Mouse Monoclonal Antibody (EAB22317) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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