| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IHC-P, IF/ICC | 123 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | c-Abl Rabbit Monoclonal Antibody detects endogenous levels of c-Abl protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
c-Abl is a non-receptor tyrosine kinase that plays a vital role in regulating cellular processes such as differentiation, division, adhesion, and response to stress. c-Abl is primarily localized in both the cytoplasm and nucleus, a distribution crucial for involvement in various signal transduction pathways and maintaining cellular homeostasis. c-Abl interacts with several key proteins, including p53, Crk, and the Ras-related GTP-binding protein p21rac, which are essential for controlling cell cycle progression and apoptosis. Dysregulation of c-Abl, often through formation of the Bcr-Abl fusion protein resulting from the Philadelphia chromosome translocation, drives development of chronic myelogenous leukemia (CML) and certain types of acute lymphoblastic leukemia (ALL). |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, HEK293 cells, using c-Abl Rabbit Monoclonal Antibody (EAB22534) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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