| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG2a | Monoclonal | WB, IHC-P, IF/ICC, ELISA | 86 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:5000-20000 IHC-P=1:500-2000 IF/ICC=1:200-1000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MFN2/Mitofusin-2 Mouse Monoclonal Antibody detects endogenous levels of MFN2/Mitofusin-2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MFN2 also known as mitochondrial fusion 2, Mitofusin-2 is a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. MFN2 plays a critical role in mitochondrial dynamics by mediating the fusion of mitochondria, which is essential for maintaining mitochondrial function and cellular energy homeostasis. This process is particularly important in tissues with high energy demands, such as heart and muscle, where MFN2 is abundantly expressed. Proper functioning of MFN2 is crucial for embryonic development and has been implicated in the pathobiology of various metabolic disorders, including obesity. Notably, MFN2 interacts with other proteins involved in mitochondrial dynamics, such as MFN1, and these interactions are vital for the formation of mitochondrial networks that support cellular metabolism. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, HepG2, Jurkat, HEK293 cells, using MFN2/Mitofusin-2 Mouse Monoclonal Antibody (EAB22345) at 1:10000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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