| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG2b | Monoclonal | WB, IF/ICC, FC, ELISA | 96 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IF/ICC=1:100-500 FC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PMS2 Mouse Monoclonal Antibody detects endogenous levels of PMS2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PMS2 also known as MLH4, PMS2CL is a key component of the mismatch repair system. PMS2 plays a critical role in the DNA mismatch repair (MMR) system, which maintains genomic stability by correcting errors during DNA replication. Deficiencies in this repair mechanism can lead to an accumulation of mutations, increasing the risk of various cancers, including hereditary nonpolyposis colorectal cancer (HNPCC). The identification of PMS2 mutations in HNPCC patients highlights PMS2′s importance in cancer predisposition and potential as a biomarker for tumorigenesis. PMS2 interacts with other key proteins in the MMR pathway, such as MLH1, forming a functional complex crucial for the repair process. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells, using PMS2 Mouse Monoclonal Antibody (EAB21241) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
|
