| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IF/ICC, ELISA | 74 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PLZF Mouse Monoclonal Antibody detects endogenous levels of PLZF protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PLZF also known as ZBTB16, ZNF145 is a member of the Krueppel C2H2-type zinc-finger protein family. PLZF plays a crucial role in transcriptional regulation and is involved in the development of various cell types, particularly in the immune system. PLZF structure is characterized by five zinc finger motifs and a broad-complex, POZ (or BTB) domain, which are essential for function as a transcription factor. PLZF BTB/POZ domain facilitates protein-protein interactions, allowing formation of complexes with other transcriptional regulators, thereby influencing gene expression. PLZF has been implicated in the regulation of genes associated with tumor suppression, and dysregulation is linked to several cancers, including acute promyelocytic leukemia, where PLZF forms a fusion protein with retinoic acid receptor alpha (RARA), leading to altered transcriptional activity. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells, using PLZF Mouse Monoclonal Antibody (EAB22041) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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