| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, IF/ICC, FC, ELISA | 68 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 IHC-P=1:100-500 IF/ICC=1:100-500 FC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | SHP-2 Mouse Monoclonal Antibody detects endogenous levels of SHP-2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SHP-2 also known as SH-PTP2, PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. SHP-2 plays a crucial role in cellular signaling by regulating the phosphorylation state of tyrosine residues on proteins, which is essential for controlling various cellular processes such as growth, differentiation, and metabolism. Located primarily in the cytoplasm, SHP-2 interacts with a variety of signaling molecules, including growth factor receptors and other phosphotyrosine-containing proteins, thereby influencing pathways that are vital for cellular responses to external stimuli. The importance of SHP-2 is underscored by its involvement in several diseases, including cancer, where dysregulation of its activity can lead to aberrant signaling and tumor progression. With its ability to modulate key signaling pathways, SHP-2 serves as a significant target for therapeutic intervention and research into cellular mechanisms. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, MCF7, Jurkat, HEK293, NIH/3T3 cells, using SHP-2 Mouse Monoclonal Antibody (EAB22789) at 1:2000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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