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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG2b | Monoclonal | WB, IHC-P, IF/ICC, ELISA | 134 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:1000-5000 IHC-P=1:100-500 IF/ICC=1:100-500 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Tyk2 Mouse Monoclonal Antibody detects endogenous levels of Tyk2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Tyk2 is a crucial member of the non-receptor Janus tyrosine kinase family, playing a pivotal role in mediating cellular responses to cytokines and interferons, which are essential for the immune system′s functionality. Located primarily in the cytoplasm, Tyk2 is recruited to activated cytokine receptors, where Tyk2 phosphorylates signal transducer and activator of transcription (STAT) proteins. This phosphorylation triggers the dimerization of STATs, allowing STATs to translocate to the nucleus and regulate the transcription of genes involved in immune responses. Proper functioning of Tyk2 is critical for maintaining immune homeostasis, as dysregulation can lead to various inflammatory diseases. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562, Jurkat, Molt-4, HEK293 cells, using Tyk2 Mouse Monoclonal Antibody (EAB21417) at 1:2000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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