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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IF/ICC | 34 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:1000-5000 IP=1:10-100 IF/ICC=1:100-500 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Cleaved Caspase-7 (Asp198) Rabbit Monoclonal Antibody detects endogenous levels of caspase-7 protein only when cleaved at Asp198. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Caspase-7 also known as MCH3, CMH-1, CASP7 is a member of the cysteine-aspartic acid protease (caspase) family. Caspase-7 play a vital role in the apoptotic process by executing programmed cell death. Caspase-7 primarily located in the cytoplasm that activates in response to apoptotic signals, where caspase-7 translocates to the nucleus to cleave specific substrates, including poly(ADP-ribose) polymerase (PARP), thereby facilitating the dismantling of cellular components during apoptosis. Caspase-7′s ability to cleave PARP into an apoptotic fragment underscores its importance in regulating cellular responses to stress and DNA damage, making caspase-7 a key player in maintaining cellular homeostasis and preventing tumorigenesis. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells treated with Staurosporine, using Cleaved Caspase-7 (Asp198) Rabbit Monoclonal Antibody (EAB22587) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 34 kDa; Observed band size: 18 kDa |
