| Biological Activity |
| Synonyms |
LEE011; LEE-011; LEE 011; Ribociclib |
| Chemical Name |
7-cyclopentyl-N,N-dimethyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide |
| Application |
LEE011 (NVP-LEE011) is a highly specific inhibitor of CDK4/CDK6 and functions via decreasing in phosphorylated RB and FOXM1. |
| CAS Number |
1211441-98-3 |
| Purity |
≥99.0% |
| Molecular Weight |
434.54 |
| Molecular Formula |
C23H30N8O |
| SMILES |
CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5 |
| Target & IC50 |
CDK4: IC50=10 nM
CDK6: IC50=39 nM |
| Shipping |
Gel Pack |
| Storage |
Store at -20°C |
| Preparing Stock Solutions |
Molecular Structure |
| ConcentrationSolventMass |
1 mg |
5 mg |
10 mg |
| 1 mM |
2.3013 ml |
11.5064 ml |
23.0128 ml |
| 5 mM |
0.4603 ml |
2.3013 ml |
4.6026 ml |
| 10 mM |
0.2301 ml |
1.1506 ml |
2.3013 ml |
| 50 mM |
0.0460 ml |
0.2301 ml |
0.4603 ml |
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