| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | IHC-P, IF/ICC | 55 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CD5 Mouse Monoclonal Antibody detects endogenous levels of CD5 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CD5 also known as LEU1 is a crucial transmembrane glycoprotein predominantly expressed on approximately 70% of normal peripheral blood lymphocytes and nearly all T lymphocytes in the thymus and peripheral blood. CD5′s primary function involves modulating T cell activation; when T cells are activated through the T cell receptor (TCR), CD5 undergoes tyrosine phosphorylation, which is essential for regulating T cell responses. Notably, absence of CD5 leads to hyper-responsiveness of T cells to TCR-mediated activation, highlighting CD5′s role in maintaining immune homeostasis. CD5 interacts with the TCR/CD3-ζ chain and the Src family kinase Lck p56, significantly enhancing Lck′s kinase activity by 10- to 15-fold when bound to CD5. |
| Product Image Gallery | |
 Immunohistochemical analysis of paraffin-embedded Human tonsil caricnoma tissue, using CD5 Mouse Monoclonal Antibody (EAB12091) at 1:200 dilution.
 Immunofluorescence analysis of Mouse heart tissue, using CD5 Mouse Monoclonal Antibody (EAB12091)(red) at 1:200 dilution.
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