| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IF/ICC, ELISA | 43 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:5000-20000 IF/ICC=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | FGFR1OP Mouse Monoclonal Antibody detects endogenous levels of FGFR1OP protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
FGFR1OP(FGFR1 oncogene partner) also known as FOP, CEP43 is a 399 amino acid protein that plays a crucial role in cellular organization by localizing to the centrosome, where FGFR1OP is essential for anchoring microtubules. This localization is vital for maintaining proper cell division and ensuring mitotic spindle stability, which is critical for accurate chromosome segregation during cell division. FGFR1OP is expressed ubiquitously, with highest levels found in kidney, heart, muscle, colon, liver, testis, and pancreas, and functions as a homodimer that interacts with proteins such as EB1 and CEP350. Chromosomal aberrations involving FGFR1OP have been linked to stem cell myeloproliferative disorder development, a condition characterized by eosinophilia and myeloid hyperplasia that can progress to acute myeloid leukemia. FGFR1OP is expressed as multiple isoforms due to alternative splicing, which may contribute to diverse functional roles in cellular processes. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, U2OS, HEK293, K562 cells, using Phospho-Mnk1 (Thr255) Rabbit Polyclonal Antibody (EAB22815) at 1:10000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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