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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, FC, ELISA | 52 | Human, Mouse, Rat, Monkey |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:100-500 FC=1:50-200 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | IRAK4 Mouse Monoclonal Antibody detects endogenous levels of IRAK4 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IRAK4 also known as Interleukin-1 Receptor-Associated Kinase 4, plays a crucial role in the innate immune response by mediating signal transduction from Toll-like receptors and interleukin-1 receptors, which are vital for the activation of the NFkB signaling pathway and MAP kinase pathways. IRAK4 is primarily located in the cytoplasm and is essential for proper immune cell functioning, as IRAK4 facilitates IRAK1 phosphorylation, thereby amplifying immune response. IRAK4 shows high expression in liver and kidney tissues, with lower levels found in other tissues, underscoring IRAK-4′s importance in maintaining immune homeostasis. IRAK-4 deficiencies can lead to severe immunological consequences, including recurrent bacterial infections and diminished response to lipopolysaccharides and interleukin-1, making IRAK4 a potential target for therapeutic interventions aimed at enhancing immune function. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Jurkat, K562, MCF7 cells, using IRAK4 Mouse Monoclonal Antibody (EAB22767) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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