| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | IHC-P, IF/ICC | 113 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
IHC-P=1:100-500 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CD21 Mouse Monoclonal Antibody detects endogenous levels of CD21 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CD21 also known as CR2 is a type I integral membrane glycoprotein that plays a crucial role in the immune system by serving as a receptor for the C3d complement fragment and the Epstein-Barr virus. CD21 expression on mature B cells, follicular dendritic cells, and certain epithelial cells is vital for B cell activation and proliferation, as CD21 enhances the signaling strength of the B cell antigen receptor (BCR) in conjunction with the co-receptor CD19. This interaction is essential for the adaptive immune response, as CD21 modulates the activation threshold of B cells, ensuring a robust and specific response to foreign antigens. Additionally, CD21 undergoes phosphorylation following B cell activation, which is a key post-translational modification that influences downstream signaling pathways and cellular outcomes. |
| Product Image Gallery | |
 Immunohistochemistry of paraffin-embedded Human tonsils tissue, using CD21 Mouse Monoclonal Antibody (EAB12055) at 1:200 dilution.
 Immunofluorescence analysis of Mouse liver tissue, using CD21 Mouse Monoclonal Antibody (EAB12055)(red) at 1:200 dilution.
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