| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 44 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | BRE Rabbit Polyclonal Antibody detects endogenous levels of BRE protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
BRE also known as BABAM2 is an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. BRE plays a crucial role in regulating apoptosis by binding to the intracellular juxtamembrane domain of the death receptor, tumor necrosis factor receptor 1 (TNF-R1), as well as the death receptor FAS. This interaction is significant because BRE downregulates TNF-alpha-induced activation of NF-kB, which is essential for maintaining cellular homeostasis and differentiation in epithelial, neural, and germ line cells. Additionally, BRE inhibits components of the death-inducing signaling complexes necessary for mitochondrial activation, thereby mediating apoptosis. BRE is predominantly expressed in the adrenal cortex, medulla, testis, and pancreas, with weaker expression observed in the thymus, thyroid, stomach, and small intestine. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, HepG2 cells, using BRE Rabbit Polyclonal Antibody (EAB11452) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
