| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG2b | Monoclonal | WB, IF/ICC, ELISA | 265 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IF/ICC=1:100-500 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CREBBP/CBP Mouse Monoclonal Antibody detects endogenous levels of CREBBP/CBP protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CREBBP also known as KAT3A, CBP is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. CREBBP plays a crucial role in gene expression regulation by acting as a co-activator for numerous transcription factors, particularly those activated by cyclic AMP signaling. CREBBP is primarily located in the nucleus, where CREBBP interacts with transcription factors like CREB, facilitating the transcription of target genes essential for processes such as cell growth, differentiation, and response to hormonal signals. CREBBP′s nuclear localization enables precise regulation of gene expression in response to various stimuli, thereby influencing cellular functions and maintaining homeostasis. CREBBP undergoes post-translational modifications, including acetylation and phosphorylation, which can further modulate CREBBP′s activity and interactions with other proteins, underscoring CREBBP′s significance in cellular signaling pathways. |
| Product Image Gallery | |
 Western blot analysis of extracts on MCF7 cells, using CREBBP/CBP Mouse Monoclonal Antibody (EAB22721) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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