| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, FC, ELISA | 22 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 FC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CLEC5A Mouse Monoclonal Antibody detects endogenous levels of CLEC5A protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CLEC5A also known as MDL1 is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. CLEC5A is a type II transmembrane receptor predominantly found on myeloid cells, including macrophages, neutrophils, and dendritic cells. CLEC5A serves as an immune sensor for various pathogens, recognizing and binding to specific glycan structures present on the surfaces of viruses and bacteria, such as dengue virus (DENV) and Japanese encephalitis virus (JEV). Upon pathogen binding, CLEC5A associates with the tyrosine-phosphorylated DAP12, leading to the release of pro-inflammatory cytokines. CLEC5A has also emerged as a potential biomarker for M2-like macrophages in the tumor microenvironment. |
| Product Image Gallery | |
 Western blot analysis of extracts on THP-1 cells, using CLEC5A Mouse Monoclonal Antibody (EAB22520) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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