| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 81 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MTA1 Rabbit Polyclonal Antibody detects endogenous levels of MTA1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MTA1 is a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. plays a crucial role as a component of the NURD (nucleosome remodeling and histone deacetylation) complex, which is essential for ATP-dependent chromatin remodeling and histone deacetylase activity. MTA1 is primarily located in the nucleus, where MTA1 facilitates transcriptional repression by promoting the association of repressor molecules with chromatin, thereby influencing gene expression. The structural integrity of MTA1, which includes a single SH3-binding motif and a zinc finger domain, is vital for function, as these domains are involved in protein-protein interactions that are critical for the assembly and activity of the NURD complex. |
| Product Image Gallery | |
 Western blot analysis of extracts on Jurkat, K562 cells, using MTA1 Rabbit Polyclonal Antibody (EAB11356) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human tonsil tissue, using MTA1 Rabbit Polyclonal Antibody (EAB11356) at 1:200 dilution.
|
