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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 33 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MBD3 Rabbit Polyclonal Antibody detects endogenous levels of MBD3 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MBD3 is a part of the methyl-CpG binding protein family, recognizing and binding to methylated cytosine residues within CpG dinucleotides, influencing transcriptional repression. MBD3 plays a crucial role in gene expression regulation through DNA methylation involvement, essential for maintaining cellular identity and function. This interaction enables gene silencing in specific cell types, contributing to development, differentiation, and genomic stability. MBD3 interacts with other methyl-CpG binding protein family members, including MBD1, MBD2, and MeCP2, forming complexes that mediate transcriptional repression in response to DNA methylation. MBD proteins show high expression in somatic tissues, highlighting their significance in gene expression regulation across various biological contexts. |
| Product Image Gallery | |
 Western blot analysis of extracts on Jurkat, Mouse brain cells, using MBD3 Rabbit Polyclonal Antibody (EAB11355) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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