| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IF/ICC, ELISA | 45 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | p75NTR Rabbit Polyclonal Antibody detects endogenous levels of p75NTR protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
p75NTR also known as TNFRSF16, CD271, NGFR p75, NGFR is a member of the TNF receptor superfamily. p75NTR plays a crucial role in the nervous system by modulating the effects of neurotrophic factors, particularly nerve growth factor (NGF). p75NTR is primarily located on the surface of neurons and is essential for neuronal survival and differentiation. By binding to neurotrophic factors with low affinity, p75NTR enhances the signaling efficiency of the high-affinity Trk receptors, such as Trk A, which is vital for the activation of downstream signaling pathways that promote neuronal health and function. The interaction between p75NTR and Trk A not only accelerates the activation of Trk A but also facilitates the recruitment of downstream effector molecules, thereby playing a significant role in the neurotrophic signaling cascade. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, HepG2, K562 cells, using p75NTR Rabbit Polyclonal Antibody (EAB11350) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 45 kDa; Observed band size: 70-75 |
