| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 87 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-Ataxin-1 (Ser776) Rabbit Polyclonal Antibody detects endogenous levels of Ataxin-1 protein only when phosphorylated at Ser776. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Ataxin-1 also known as SCA1, ATNX1 is differentially expressed and localizes to both the cytoplasm and the nucleus. Ataxin-1 plays a crucial role in regulating gene expression and cellular signaling pathways, particularly in the central nervous system. Proper Ataxin-1 function is vital for maintaining neuronal health, and mutations in Ataxin-1 are linked to the autosomal dominant neurodegenerative disorder spinocerebellar ataxia type 1 (SCA-1), which leads to progressive neuronal loss, muscle wasting, and ataxia. Ataxin-1 is predominantly localized in the cytoplasm and nucleus, where Ataxin-1 interacts with key proteins such as the Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and the nuclear matrix-associated protein promyelocytic leukemia protein (PML). |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2 cells treated with Adriamycin, using Phospho-Ataxin-1 (Ser776) Rabbit Polyclonal Antibody (EAB11297) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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