| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 71 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | UBA2 Rabbit Polyclonal Antibody detects endogenous levels of UBA2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
UBA2 plays a crucial role in the sumoylation process, which is essential for regulating various cellular functions. Sumoylation, unlike ubiquitination that primarily targets proteins for degradation, modifies proteins to influence stability, localization, and activity, thereby impacting processes such as nuclear transport and transcriptional regulation. UBA2, along with homolog AOS1, forms a heterodimer that activates SUMO-1, facilitating conjugation to target proteins, including key regulators like p53 and MDM2. This interaction maintains cellular homeostasis and responds to stress, making UBA2 a significant player in cellular signaling pathways. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293 cells, using UBA2 Rabbit Polyclonal Antibody (EAB11252) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemistry analysis of paraffin-embedded Human lung carcinoma tissue, using UBA2 Rabbit Polyclonal Antibody (EAB11252) at 1:100 dilution.
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