| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 42 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:1000-5000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | DUSP6/MKP3 Rabbit Polyclonal Antibody detects endogenous levels of DUSP6/MKP3 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MKP3 also known as DUSP6 is a member of the dual specificity protein phosphatase subfamily. plays a crucial role in regulating mitogen-activated protein (MAP) kinase signaling pathways, which are essential for cellular responses to growth factors and stress signals. By specifically dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases, MKP3 serves to inactivate members of the extracellular signal-regulated kinase (ERK) family, thereby modulating various physiological processes such as cell proliferation, differentiation, and apoptosis. MKP3 expression is tightly regulated and can be induced by various stimuli, highlighting MKP3′s importance in maintaining cellular homeostasis and preventing aberrant signaling that could lead to pathological conditions. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2, NIH/3T3, Rat heart cells, using DUSP6/MKP3 Rabbit Polyclonal Antibody (EAB11245) at 1:3000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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