| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG2b | Monoclonal | WB, IHC-P, IF/ICC, FC, ELISA | 35 | Human |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:100-500 IF/ICC=1:100-500 FC=1:50-200 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | UFD1 Mouse Monoclonal Antibody detects endogenous levels of UFD1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
UFD1 plays a crucial role in the ubiquitin-proteasome system, which is essential for maintaining cellular homeostasis by regulating protein degradation. UFD1 is primarily located in the cytoplasm and nucleus, where UFD1 participates in the recognition and processing of ubiquitin-conjugated substrates, thereby influencing the degradation of misfolded or damaged proteins. Proper functioning of UFD1 is vital, as dysregulation can lead to the accumulation of harmful proteins, contributing to various diseases, including neurodegenerative disorders. Notably, mutations in the UFD1 gene have been linked to CATCH22 syndrome, underscoring UFD1′s importance in developmental processes and potential implications in human health. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, K562, A431, A549 cells, using UFD1 Mouse Monoclonal Antibody (EAB21182) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissue, using UFD1 Mouse Monoclonal Antibody (EAB21182) at 1:200 dilution.
 Immunofluorescence analysis of Hela cell, using UFD1 Mouse Monoclonal Antibody (EAB21182)(green) at 1:200 dilution.
 Flow cytometric analysis of Hela cell, using UFD1 Mouse Monoclonal Antibody (EAB21182)(green) and negative control (red).
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