| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 81 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-KIF2C (Ser95) Rabbit Polyclonal Antibody detects endogenous levels of KIF2C protein only when phosphorylated at Ser95. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
KIF2C also known as MCAK is a member of the kinesin-like family of proteins. KIF2C plays a crucial role in regulating microtubule dynamics during cell division, which is essential for accurate chromosome segregation. KIF2C is a protein primarily located in the cytoplasm and nucleus, where KIF2C associates with the centromere during early prophase and disassociates after telophase, ensuring proper chromosome alignment and separation. KIF2C is particularly abundant in thymus and testis, indicating importance in cellular processes related to these tissues, while showing lower expression in small intestine, mucosal lining of colon, and placenta. KIF2C′s interaction with microtubules and other proteins involved in mitotic spindle assembly makes KIF2C vital for maintaining genomic stability, and dysregulation has been implicated in various cancers, suggesting potential as a therapeutic target. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells treated with TNF, using Phospho-KIF2C (Ser95) Rabbit Polyclonal Antibody (EAB11191) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
 Immunohistochemical analysis of paraffin-embedded Human gastric adenocarcinoma tissue, using Phospho-KIF2C (Ser95) Rabbit Polyclonal Antibody (EAB11191) at 1:200 dilution.
 Immunofluorescence analysis of A549 cell, using Phospho-KIF2C (Ser95) Rabbit Polyclonal Antibody (EAB11191) at 1:200 dilution.
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