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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, ELISA | 65 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:1000-5000 IHC-P=1:100-500 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Malic Enzyme 2/ME2 Mouse Monoclonal Antibody detects endogenous levels of Malic Enzyme 2/ME2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
ME2 also known as malic enzyme 2 is a crucial mitochondrial enzyme that plays a significant role in cellular metabolism by catalyzing the conversion of (s)-malate to pyruvate, a key step in the anaplerotic pathway. This enzymatic function is vital for maintaining the balance of metabolic intermediates, which is essential for energy production and biosynthesis in cells. Notably, ME2 exists as a homotetramer, and ME2 activity is intricately linked to the malate-aspartate shuttle, which is critical for the transport of reducing equivalents across the mitochondrial membrane. Dysregulation of ME2 has been implicated in various neuropsychiatric disorders, including schizophrenia and bipolar disorder, highlighting ME2 importance in neuronal function and neurotransmitter synthesis. |
| Product Image Gallery | |
 Western blot analysis of extracts on HL60, NIH/3T3, Jurkat cells, using Malic Enzyme 2/ME2 Mouse Monoclonal Antibody (EAB22553) at 1:2000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
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