| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 239 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IHC-P-Immunohistochemistry-Paraffin |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | DOCK8 Rabbit Polyclonal Antibody detects endogenous levels of DOCK8 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
DOCK8(Dedicator of cytokinesis 8) a member of the DOCK180 family of guanine nucleotide exchange factors. DOCK8 functions as a guanine nucleotide exchange factor (GEF) that may play a role in protein activation and is thought to influence Actin organization. Defects in the gene encoding DOCK8 are associated with the pathogenesis of autosomal dominant mental retardation (MRD2), possibly due to errors in Actin-based cytoskeletal structure. Mutations in this gene also result in the autosomal recessive form of the hyper-IgE syndrome, a rare disorder characterized by immunodeficiency, recurrent infections, eczema, increased serum IgE, eosinophilia and lack of connective tissue and skeletal involvement. Multiple isoforms of DOCK8 exist due to alternative splicing events. |
| Product Image Gallery | |
 Western blot analysis of extracts on dA549, NIH/3T3 cells, using DOCK8 Rabbit Polyclonal Antibody (EAB11174) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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